Processing of myelin basic protein by macrophages generates an epitope with apparent low affinity for I-As.

نویسندگان

  • P J Fairchild
  • E S Cohen
  • D C Wraith
چکیده

30 Brichard, V., Van Pel, A., Wolfel, T. et al. (1993) J. Exp. Med. 178,489-495 Coulie, P. G., Brichard, V., Van Pel, A. et al. (1994) J. Exp. Med. 180,35-42 Barker, C. F. and Billingham, R. E. (1977) Adv. Immunol. 25,l-54 Haas, G. G., Jr., DCruz, 0. J. and De Bault, L. E. (1988) Am. J. Reprod. Immunol. Microbiol. 18,47-5 1 Traversari, C., van der Bruggen, P., Van den Eynde, B. et al. (1992) Immunogenetics 35, 145-152 De Plaen, E., Arden, K., Traversari, C. et al. (1994) Immunogenetics 40,360-369 Brasseur, F., Marchand, M., Vanwijck, R. et al. (1992) Int. J. Cancer 52,839-841 Weynants, P., Lethb, B., Brasseur, F., Marchand, M. and Boon, T. (1994) Int. J. Cancer 56,826-829 Traversari, C., van der Bruggen, P., Luescher, I. F. et al. (1992) J. Exp. Med. 176, 1453-1457 van der Bruggen, P., Szikora, J.-P., Boel, P. et al. (1994) Eur. J. Immunol. 24,2 134-2 140 31 Gaugler, B., Van den Eynde, B., van der Bruggen, P. et al. (1994) J. Exp. Med. 179,921-930 32 van der Bruggen, P., Bastin, J., Gajewski, T. et al. (1994) Eur. J. Immunol. 24, 3038-3043 33 Boel, P., Wildmann, C., Sensi, M.-L. et al. (1995) Immunity 2, 167-175 34 Nordlund, J. J., Kirkwood, J. M., Forget, B. M., Milton, G., Albert, D. M. and Lerner, A. B. (1983) J. Am. Acad. Dermatol. 9,689-696 35 Bystryn, J.-C., Darrell, R., Friedman, R. J. and Kopf, A. (1987) Arch. Dermatol. 123, 1053-1055 36 Wolfel, T., Van Pel, A., Brichard, V. et al. (1994) Eur. J. Immunol. 24,759-764 37 Kawakami, Y., Eliyahu,S., Delgado, C. H. et al. (1994) Proc. Natl. Acad. Sci. USA. 91, 3515-3519 38 Kawakami, Y., Eliyahu, S., Sakaguchi, K. et al. (1994) J. Exp. Med. 180,347-352

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

ISOLATION OF MYELIN BASIC PROTEIN AND DETECTION OF I TS IMMUNOL\'OGICAL PROPERTIES

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system of presumed autoimmune etiology. One of the best animal models of demyelinating diseases is experimental autoimmune encephalomyelitis (EAE), which can be induced in a variety of animals by injection of a target antigen such as myelin basic protein (MBP). The immune responses against the target amino acids caus...

متن کامل

In silico design a multivalent epitope vaccine against SARS-CoV-2 for Iranian populations

Background: Due to high genetic variation in human leukocyte antigen )HLA( alleles, epitope-based vaccines don’t show equal efficacy in different human populations. therefore, we proposed a multi-epitope vaccine against SARS-CoV-2 for Iranian populations. Materials and Methods: For this purpose, the proteins without allergenicity and high antigenicity as well as conservancy level from SARS-CoV...

متن کامل

Competition Between Two MHC Binding Registers in a Single Peptide Processed from Myelin Basic Protein Influences Tolerance and Susceptibility to Autoimmunity

Experimental allergic encephalomyelitis (EAE) is an animal model for multiple sclerosis induced by stimulating myelin basic protein (MBP)-specific T cells. The MBP-specific repertoire in B10.PL mice is shaped by tolerance mechanisms that eliminate MBP121-150-specific T cells. In contrast, MBPAc1-11-specific T cells escape tolerance and constitute the encephalitogenic repertoire. To determine if...

متن کامل

Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice.

Genes of the MHC show the strongest genetic association with multiple sclerosis (MS), but the underlying mechanisms have remained unresolved. In this study, we asked whether the MS-associated MHC class II molecules, HLA-DRB1*1501, HLA-DRB5*0101, and HLA-DRB1*0401, contribute to autoimmune CNS demyelination by promoting pathogenic T cell responses to human myelin basic protein (hMBP), using thre...

متن کامل

Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker

Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...

متن کامل

In Silico Perspectives on the Prediction of the PLP’s Epitopes involved in Multiple Sclerosis

Background: Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS). The main cause of the MS is yet to be revealed, but the most probable theory is based on the molecular mimicry that concludes some infections in the activation of T cells against brain auto-antigens that initiate the disease cascade.Objectives: The Purpose of this research is the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 23 3  شماره 

صفحات  -

تاریخ انتشار 1995